Weight loss is a journey many individuals undertake to improve their health and well-being. With advancements in medical science, innovative therapies are emerging to support this goal.
Among these, AOD 9604 and Semaglutide have gained attention for their potential to promote weight loss effectively. However, understanding their differences can help you make an informed decision about which treatment aligns best with your needs.
This blog will explore these two options, their benefits, side effects, costs, and whether they can be used together. If you’re considering advanced medical weight loss solutions, Hormone Replacement Therapy LA clinic can guide you toward achieving your goals.
AOD 9604 vs. Semaglutide: Key Differences
Weight Loss Effectiveness
AOD 9604 is a synthetic peptide derived from the human growth hormone (HGH). Early clinical trials have shown that AOD 9604 effectively promotes fat loss without causing the significant side effects often associated with growth hormone therapy [1].
Studies also suggest that it may eventually be developed into an orally available and safe therapeutic agent for obesity, making it a convenient option for patients [2].
Semaglutide, on the other hand, is a GLP-1 receptor agonist originally designed to manage type 2 diabetes. However, its weight loss benefits have been widely documented.
A large study of 2,000 obese adults found that participants using semaglutide combined with diet and exercise lost up to 15-20% of their body weight after 68 weeks. By comparison, those who made lifestyle changes alone lost only about 2.4% of their weight [3].
For individuals seeking rapid and significant weight loss, Semaglutide stands out as the more effective option.
Side Effects and Safety
Both AOD 9604 and Semaglutide are generally considered safe, but they have different side effect profiles:
- AOD 9604: This peptide has minimal reported side effects in clinical studies, making it a safer option for individuals who are sensitive to traditional growth hormone therapy. Beyond its weight loss benefits, AOD 9604 has shown potential for cartilage regeneration when used in intra-articular injections combined with hyaluronic acid (HA), particularly in joint health conditions [4].
- Semaglutide: Common side effects include nausea, vomiting, diarrhea, and constipation, particularly when starting treatment. However, these symptoms often subside over time as the body adjusts. Additionally, research suggests that semaglutide may also reduce A1C levels in people with or without diabetes, making it a dual-purpose treatment [5].
Costs Considerations
The cost of treatment can be a deciding factor for many patients:
- AOD 9604: As a relatively newer option, AOD 9604 is often less expensive than Semaglutide. However, the lack of extensive studies and FDA approval for weight loss specifically may deter some patients.
- Semaglutide: Although highly effective, Semaglutide treatments can be costly, especially for long-term use. Insurance coverage varies, and out-of-pocket expenses may be significant for those without coverage.
When choosing between these treatments, it’s important to weigh the cost against the expected benefits and outcomes.
Why Semaglutide is Better than AOD 9604 for Weight Loss
Semaglutide’s extensive clinical backing and proven effectiveness make it the superior option for weight loss. Research has confirmed that it can produce remarkable fat loss results, often exceeding those of lifestyle changes alone [6]. Additionally, its dual benefits in managing blood sugar and improving overall metabolic health add to its appeal.
While AOD 9604 is promising, its weight loss effects are more subtle and may require a longer time to see significant results. Semaglutide, by contrast, offers:
- Faster and more significant weight loss
- Comprehensive benefits for individuals with or without diabetes
- Established safety and effectiveness in large-scale clinical trials
If achieving substantial weight loss is your primary goal, Semaglutide is likely the better choice.
Can You Take Semaglutide and AOD 9604 Together?
Combining treatments is a common strategy in medical weight loss, but it should always be done under the supervision of a healthcare provider.
While there’s no direct evidence suggesting harm in using Semaglutide and AOD 9604 together, there’s limited research on their combined efficacy. AOD 9604’s potential for fat metabolism enhancement could complement Semaglutide’s appetite-suppressing properties, creating a synergistic effect. However, it’s essential to monitor for potential interactions or compounded side effects.
At Hormone Replacement Therapy LA clinic, our specialists can assess your individual needs and develop a tailored treatment plan, possibly incorporating both therapies for maximum benefit.
Final Words
Choosing between AOD 9604 and Semaglutide depends on your health goals, budget, and tolerance for potential side effects. While AOD 9604 offers a safer and potentially cost-effective approach with added joint health benefits, Semaglutide stands out as the most effective option for significant weight loss, supported by robust clinical research.
If you’re unsure which option is right for you, scheduling a consultation at Hormone Replacement Therapy LA clinic is the best way to start your journey. Our experts will provide personalized guidance, ensuring you receive the most effective treatment tailored to your unique needs.
Take the first step toward a healthier, happier you—schedule your consultation today!
References:
- Misra M. Obesity pharmacotherapy: current perspectives and future directions. Curr Cardiol Rev. 2013;9(1):33-54. doi:10.2174/157340313805076322
- Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278. doi:10.1159/000053183
- Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine. 2021;384(11):989-1002. doi:https://doi.org/10.1056/nejmoa2032183
- Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015;45(4):426-432.
- Chubb, B., Gupta, P., Gupta, J. et al. Once-Daily Oral Semaglutide Versus Injectable GLP-1 RAs in People with Type 2 Diabetes Inadequately Controlled on Basal Insulin: Systematic Review and Network Meta-analysis. Diabetes Ther 12, 1325–1339 (2021). https://doi.org/10.1007/s13300-021-01034-w
- Tan HC, Dampil OA, Marquez MM. Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis. J ASEAN Fed Endocr Soc. 2022;37(2):65-72. doi:10.15605/jafes.037.02.14
