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Progesterone Hormone Replacement Therapy


Progesterone Replacement Therapy

You might have an imbalance of progesterone if you’ve recently been exhausted or experienced irregular periods. You may take progesterone and estrogen as part of hormonal replacement therapy because they are hormones generated in the ovaries.

If you go through menopause or have an imbalance for another cause, your doctor or healthcare provider may recommend hormone replacement therapy (HRT) for low progesterone levels.

What is Progesterone Replacement Therapy?

We can work with you to determine whether you might be a candidate for progesterone replacement therapy if you have any of these kinds of symptoms. You might also be interested in learning more about bioidentical replacement therapy, another name for natural hormone therapy.


This can be a fantastic alternative if you want a hormone made from animal or plant materials that is more naturally occurring. Similar to the progesterone your body would naturally make is bioidentical progesterone. We can go over the advantages of bioidenticals with you as a component of a comprehensive wellness and hormone replacement program.


You may have various favorable effects from hormone replacement therapy, such as improved mood, fewer hot flashes, and a decreased risk of Alzheimer’s disease.

What is Progesterone Replacement Therapy

Types of Progesterone/Progestin Hormone Therapy

Oral Progestins

Medroxyprogesterone acetate (Provera) and synthetic progestins are two examples of orally administered progestin medicines (norethindrone, norgestrel). Natural progesterone, rather than synthetic progestins, is the treatment for most specialists when dealing with menopausal individuals.


According to studies, natural progesterone may not affect lipids negatively, making it a good option for women with excessive cholesterol. Natural progesterone may also have benefits beyond those of medroxyprogesterone acetate.

Intrauterine Progestin

Liletta, Kyleena, Mirena, and Skyla all refer to different types of low-dose intrauterine devices (IUDs) containing levonorgestrel. In the United States, they are accepted for the treatment of abnormal bleeding and the prevention of pregnancy, and they are also sometimes taken “off-label” alongside estrogen alone.


Your doctor may recommend you maintain the IUD until perimenopause is over if you have one of these devices and are experiencing irregular periods due to perimenopause.

Get a Consultation on Which One Fits You at +1 424-283-4273

What is progesterone?

The pregnancy hormone is often referred to as progesterone. In the reproductive years of women’s health, progesterone affects how the uterus prepares for pregnancy.

Additionally, it affects the production of breast milk and the development of a mucus barrier around the cervix.


Progesterone influences a variety of other bodily processes as well, so if your ovaries aren’t producing enough of it, you might notice:

Differences between progestins and progesterone

In contrast to progesterone, the progestins utilized in nations where most epidemiological studies have been conducted differ from any FDA-approved studies.


Indirect actions (metabolic and hepatocellular) may stimulate BC cells in conjunction with estrogens and improve estrogen bioavailability, and they may also have direct effects on normal and cancerous breast cells.

Why are estrogen and progesterone together in HRT?

Your uterus continues to shed its lining (the endometrial) every month so long as you continue to have periods. The endometrium stays in place after menstruation stops.


The chance of developing endometrial cancer rises in women who use dose of estrogen because the hormone encourages the lining to thicken. Estrogen replacement therapy using different types of estrogen keeps the consistency of the lining using conjugated estrogens. Incorporating progesterone with HRT has been shown to maintain a thin uterine lining and lower ovarian cancer risk. It also enhances the effects of estrogen.

Symptoms of Progesterone Imbalance

Postmenopausal women may have additional signs of progesterone hormone imbalance and symptoms of menopause, like exhaustion and irregular periods. These could include breast pain, heat flashes, vaginal dryness, and urinary tract infections.


Psychological symptoms like anxiety, memory loss, mood changes, and sadness could also manifest in postmenopausal women. It’s critical to seek systemic therapy for low progesterone since it can make your bones more brittle and increase your chance of developing certain cancers.

Side effects of progesterone therapy

Side effects of progesterone therapy

You might be allergic to progesterone, or you might encounter any of the following adverse effects:

  • fatigue, headache, nausea, or gastrointestinal pain
  • weight gain or fluid retention
  • breast tenderness
  • risk of breast cancer
  • uterine bleeding
  • risk of endometrial cancer

Who shouldn’t go for progesterone replacement therapy?

Not everyone should take progesterone. Inquire with your doctor about progesterone substitutes if you:

  • Are more likely to develop dementia, heart diseases, strokes, blood clots, osteoporosis, or liver disease
  • Over 60 with cardiovascular issues
  • Have been menopausal for more than 10 years,
  • Have a personal or family history of breast cancer,
  • heart attack, high cholesterol, blood pressure or
  • Any combination of these conditions.

Home Remedies for menopause symptoms

There are alternatives to menopausal hormone therapy for alleviating menopausal symptoms and maintaining women’s health.

  • Take organic foods. Hot flashes and night sweats may be alleviated using natural remedies such as black cohosh or evening primrose oil.
  • Do frequent exercise. Exercising can help you keep the weight off, enhance sleep, reduce cholesterol, and calm the jitters and mood swings accompanying menopause.
  • Watch your portion sizes and what you eat. Avoiding spicy foods, caffeine, and alcohol can prevent hot flashes and night sweats.
  • Learn effective methods for dealing with stress. You may have trouble sleeping and feeling happy if you’re under a lot of stress. As a side effect, it can make hot flashes more common. If you’re having trouble keeping stress at bay, try relaxation techniques like yoga, tai chi, deep breathing exercises, or even just spending time doing something you enjoy.

HRT Alternatives

Bioidentical hormones

Bioidentical hormones are plant-based solutions marketed as safe and effective alternatives to synthetic hormones. Traditional HRT practitioners argue that their clients would benefit more from the systemic use of these “natural” hormones.


Bioidentical preparations, on the other hand, are discouraged because

  • There is no reliable evidence that they are safer than conventional HRT and are not regulated; thus, it is unclear whether they are safe.

  • There is no data on their efficacy in treating menopause symptoms.

  • Saliva hormone levels are commonly utilized as a basis for bioidentical preparations, despite a lack of evidence connecting saliva hormone levels and illness presentation.


For some women, antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs) can alleviate the discomfort of menopausal hot flashes.


The FDA has not approved these medications for your condition. Your doctor will discuss the benefits and hazards of these treatments with you, as they have not been tested in clinical trials to see if they improve this problem.


Anxiety, trembling, nausea, dizziness, and decreased libido are potential negative reactions to SSRIs and SNRIs. In most cases, negative reactions subside on their own, but if yours hasn’t by now, visit a doctor to maintain your quality of life.


Tibolone, sold under the trade name Livial, is a prescription drug miming the effects of combined hormone replacement therapy (estrogen and progestogen). The recommended dosage is one tablet daily.


Although some research suggests it may not be as effective as combined HRT, it can help alleviate symptoms, including hot flashes, low mood, and decreased sex drive. Only women who have gone beyond a few years of menopause should use it (known as post-menopause).


Abdominal (tummy) pain, pelvic pain, breast tenderness, itchiness, and vaginal discharge are possible negative reactions to tibolone. Dangers of tibolone include an increased risk of breast cancer and strokes, which are also risks of HRT. Consult your doctor about the potential adverse effects and benefits of tibolone.


Dr. David Nazarian can offer you the most effective solutions if you are in Beverly Hills and looking for a complete HRT package. Call +1 424-283-4273 to get the most effective Progesterone Replacement Therapy in LA that is tailored for you.

Start your hormone replacement program today and become your best self

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