Tirzepatide is a GLP-1 and GIP receptor agonist that has shown promise in the treatment of type 2 diabetes and weight loss. More researches are needed to prove that tirzepatide indeed causes weight loss. However, there are still some studies that claim that tirzepatide causes weight loss. Let’s talk more about Tirzepatide in the Hormone Replacement Therapy clinic.
What is Tirzepatide?
Tirzepatide is a synthetically made drug used to treat type 2 diabetes. It is the first drug that is made from glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist, which are used to treat type 2 diabetes mellitus as a single therapy or with other diabetes medicines [1].
Still, it is not approved for treating type-1 diabetes mellitus and has not been studied in patients with pancreatitis.
What is the brand name of tirzepatide?
Tirzepatide is marketed under the brand names Mounjaro and Zepbound.
What class of drug is tirzepatide?
Tirzepatide is an incretin mimetic drug. It contains both GIP and GLP-1 hormones. Because it contains both the incretin hormones (stimulates cells in the pancreas to release insulin), it is also called Twincretin [2].
How it works
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Yes. Tirzepatide can be used for weight management in adults with obesity. It works by lowering appetite and slowing down food digestion and absorption, giving the feeling of fullness more quickly and for a long time. A study conducted with obese patients stated that treatment with tirzepatide had an average weight loss of 10%-20% of their body weight after 72 weeks [3].
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How effective is tirzepatide for weight loss?
A study conducted by Eli Lilly amongst users achieved a total average weight loss of 26.6% over 84 weeks. Another Cleveland Clinic study showed that 2500 obese adults taking 5 mg of Mounjaro (tirzepatide) for 72 weeks lost 15% of their body weight [4].
Side effects of Mounjaro
Abdominal pain or discomfort
Constipation
Decreased appetite
Diarrhea
Nausea and vomiting
More serious side effects include:
Acute gallbladder disease
Acute kidney injury
Hypoglycemia
Gastroparesis
Pancreatitis
Vision changes
Is tirzepatide the same as Ozempic?
No, tirzepatide and ozempic are not the same drugs. Ozempic is a GLP-1 receptor agonist used for treating type 2 diabetes. Tirzepatide is a dual GLP-1 and GIP receptor agonist that improves blood sugar (glucose) levels and also decreases appetite.
How much does tirzepatide cost?
The cost for Tirzepatide subcutaneous solution (2.5 mg/0.5 mL) is around $1,135 for a supply of 2 milliliters. However, you can save on your prescription by using a savings card, a 90-day supply, or a manufacturer coupon.
Is tirzepatide bad for the kidneys?
Not at all. In fact, a study concluded that Tirzepatide may help protect the kidneys in people with type 2 diabetes [5]. It helps slow down the decline of kidney function (eGFR) and prevents the growth of protein in the urine, which is called microalbuminuria. This helps people with chronic kidney disease or those at a high risk of heart disease.
Tirzapatide vs. Semaglutide
Tirzepatide and semaglutide are both type 2 diabetes drugs that are most often used for treating weight loss. While studies showed that tirzepatide is more effective [6], it’s too early to have the final say as substantial research is needed. Both drugs can increase satiety.
Tirzepatide (Mounjaro) contains glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) agonists. Tirzepatide mimics the GLP-1 hormone and the GIP hormone. The GIP hormone can also trigger insulin production and your sense of fullness, which could help with weight loss.
Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist sold under brand names such as Ozempic, Wegovy, and Rybelsus. The FDA has approved Wegovy for managing weight.
Tirzepatide For Weight Loss
Hormone Replacement Therapy LA offers the best Tirzepatide for weight loss near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.
Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine. 2022;387(3):205-216. doi:https://doi.org/10.1056/nejmoa2206038
Jastreboff AM, Aronne LJ, Ahmad N, et al. Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine. 2022;387(3):205-216. doi:https://doi.org/10.1056/nejmoa2206038
Catalina Bosch, Sol Carriazo, María José Soler, Alberto Ortiz, Beatriz Fernandez-Fernandez, Tirzepatide and prevention of chronic kidney disease, Clinical Kidney Journal, Volume 16, Issue 5, June 2023, Pages 797–808, https://doi.org/10.1093/ckj/sfac274
Azuri J, Hammerman A, Enis Aboalhasan, Sluckis B, Ronen Arbel. Tirzepatide versus semaglutide for weight loss in patients with type 2 diabetes mellitus: A value for money analysis. Diabetes, Obesity and Metabolism. 2022;25(4):961-964. doi:https://doi.org/10.1111/dom.14940
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Hormones are pivotal in our overall well-being, influencing everything from our energy levels and mood to our sleep quality and libido. As we age, hormone
Many patients are prescribed levothyroxine, a synthetic form of the thyroid hormone, to manage thyroid conditions. Meanwhile, estrogen, a critical hormone in the female reproductive