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Thymosin Beta-4

Thymosin Beta-4 - HRT

Various research studies have shown the effectiveness of Thymosin Beta-4 in many therapeutic applications. We have discussed them down below, so if this is a topic of interest to you, keep on reading.

A word of caution, though, don’t just start using Thymosin Beta-4 or any other medicines without a prior consultation with a healthcare professional. So, we’d encourage you to talk to us first if you’re considering this medication. Reach out to us at Hormone Replacement Therapy Los Angeles.

What is Thymosin Beta-4 (TB-500)?

Thymosin Beta-4, also known as TB-500, is a small, endogenous peptide comprising 43 amino acids originally isolated from the Thymus gland. It comes from the ‘Thymosin’ family of lymphocyte growth factors and is found in the thymus gland, spleen, and peritoneal macrophages.

How does TB-500 work in the body?

TB-500 primarily upregulates actin, a cell-building protein that plays a crucial role in cell structure, movement, and tissue repair. By enhancing actin production, TB-500 promotes tissue regeneration, wound healing, and overall cellular health.

What are the potential therapeutic applications of TB-500?

TB-500, also known as Thymosin Beta-4, has several promising therapeutic applications:

  • Tissue Repair and Regeneration: TB-500 promotes tissue repair by upregulating the production of actin, a protein essential for cell structure and movement. It accelerates healing in various injuries, including muscle, tendon, and ligament injuries.
  • Wound Healing: TB-500 enhances wound healing, making it valuable for treating chronic wounds, ulcers, and other skin injuries.
  • Reducing Chronic Inflammation: By reducing inflammation, TB-500 contributes to overall health and well-being.
  • Heart Repair: It may aid in repairing heart injuries and support cardiovascular health.
  • Immune System Support: TB-500 strengthens the immune system, helping the body fight infections.
  • Neurological Conditions: Some evidence suggests TB-500 could be beneficial for treating certain neurological disorders.
  • Eye Damage Repair: TB-500 shows promise in repairing eye-related damage.

How it works

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Is TB-500 legal to use?

TB-500 is not legal for use in sports and is banned by organizations like the World Anti-Doping Agency (WADA). However, it is recommended for individuals with musculoskeletal injuries, organ injuries, and those seeking endurance enhancement. Caution and guidance from experts are essential when using TB-500

How is TB-500 administered?

  • Subcutaneous Injection: Injected just under the skin, allowing for precise dosing and diverse therapeutic applications. It’s absorbed efficiently into the bloodstream.
  • Intramuscular Injection: Directly into the muscle, potentially providing a sustained release of the peptide.
  • Intravenous Injection: Administered into a vein, usually under medical supervision2.
  • Nasal Spray: A non-invasive option that ensures targeted absorption of TB-500 into the bloodstream, beneficial for healing muscle, ligament, tendon, and joint issues

What are the potential side effects of TB-500?

  • Head Rush: Some users experience a sudden rush of blood to the head after administration.
  • Lethargy/Fatigue: Feelings of tiredness or low energy levels.
  • Nausea: Occasional stomach discomfort.
  • Headache: Mild headaches may occur.
  • Skin Irritation: Injection-related skin irritation (common with peptide injections).
  • Possible Energy Crash: Despite an initial increase in energy during workouts, some users report a subsequent crash.

What are the potential side effects of TB-500

Is TB-500 safe for human use?

TB-500 is not legal for sports use and is banned by organizations like WADA.

Recommended for individuals with musculoskeletal injuries and organ damage, but caution is advised

How long does it take to see results from TB-500 treatment?

  • Initial Effects: Some patients notice positive effects within the first week of TB-500 treatment.
  • Clinical Studies: However, clinical studies indicate that you need to take TB-500 for at least three months to see noticeable results, especially for wound healing and enhanced mobility.
  • Dosage Impact: The speed of results may also depend on your dosage.

What is the current status of research on Thymosin Beta-4?

A study with Mdx mice was conducted to investigate the effects of Thymosin Beta-4. The mice were treated with Tβ4 over 6 months along with exercises to induce muscle pathology. The treated mice showed an increase in skeletal muscle regenerating fiber [1].

Research supports Tβ4’s multifaceted role in promoting cardiac health and recovery. The research stated that Thymosin Beta-4 is essential for tissue repair and nerve healing and may help treat myocardial infarction, stroke, and various nerve injuries [2].

According to another research paper published in 2010 stated that local treatment with Thymosin Beta-4 (Tβ4) enhances wound healing with minimal scarring, improves collagen organization, and reduces myofibroblast presence, leading to less scarring and stronger tissue repair [3].

A study explored the use of Thymosin Beta-4 eye drops for severe dry eye in nine human participants. After 56 days of treatment, the group receiving the eye drops experienced a 35% decrease in eye discomfort, a 59% improvement in dry eye testing parameters, and an increase in tear production. [4].

Another study looked at venous ulcers, which happen when blood doesn’t flow well and usually appear on the lower leg. They studied 73 people and found that using a 0.03% synthetic thymosin-beta 4 helped wounds heal faster. It also led to full healing in 25% of patients within three months [5].

Thymosin Beta-4 Near Me

Hormone Replacement Therapy LA offers the best Thymosin Beta-4 near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.


  1. Spurney CF, Cha HJ, Sali A, et al. Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PLoS One. 2010;5(1):e8976. Published 2010 Jan 29. doi:10.1371/journal.pone.0008976
  2. Bjørklund G, Dadar M, Aaseth J, Chirumbolo S. Thymosin β4: A Multi-Faceted Tissue Repair Stimulating Protein in Heart Injury. Curr Med Chem. 2020;27(37):6294-6305. doi: 10.2174/0929867326666190716125456. PMID: 31333080.
  3. Ehrlich HP, Hazard SW 3rd. Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts. Ann N Y Acad Sci. 2010 Apr;1194:118-24. doi: 10.1111/j.1749-6632.2010.05483.x. PMID: 20536458.
  4. Sosne G, Dunn SP, Kim C. Thymosin β4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial. Cornea. 2015 May;34(5):491-6. doi: 10.1097/ICO.0000000000000379. PMID: 25826322.
  5. Guarnera G, DeRosa A, Camerini R; 8 European sites. The effect of thymosin treatment of venous ulcers. Ann N Y Acad Sci. 2010 Apr;1194:207-12. doi: 10.1111/j.1749-6632.2010.05490.x. PMID: 20536470.

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