GHK-Cu Peptide

Restructuring Tissue

Treatments for skin aging and damage may benefit from the use of GHK-Cu peptides since it has been demonstrated that they encourage tissue remodeling.

Essential Synthesis Of Proteins

GHK-Cu peptides may have uses in wound healing and skin regeneration as they have been shown to initiate the synthesis of vital proteins for tissue healing.

GHK (glycyl-L-histidyl-L-lysine) is a human plasma copper-binding peptide that declines during aging. Numerous studies have established many biological actions of GHK: it improves tissue regeneration, possesses anti-oxidant and anti-inflammatory effects, increases cellular stemness; increases decorin, angiogenesis, and nerve outgrowth. [1]

Is It Safe To Use GHK-Cu Peptide On All Skin Types?

GHK-Cu peptide has a lot of potential, but it’s important to think about which skin types it works best for.

Although patch testing is advised prior to use, typically for those with sensitive or reactive skin, GHK-Cu is generally well tolerated. 

Finding the ideal GHK-Cu Products for your unique skin concerns can also be facilitated by speaking with a dermatologist or other skincare specialist.

The permeation rate of GHK-Cu through the stratum corneum seems high, the highest of all three skin strata studied. It seems consistent with a model of porous transport, as appendageal penetration is considered to be one, if not the predominant pathway for the diffusion of multipolar ions [24–26]. In addition, the high penetration level through the stratum corneum alone can be explained by the fact that there was no tissue retention from underlying skin that may have limited penetration. [2]

Does The GHK-Cu Peptide Hold The Key To Eternal Youth?

Given the recent buzz surrounding GHK-Cu peptide, one might legitimately wonder if we’ve discovered the proverbial fountain of youth. Before we get too excited about ideas of endless beauty, let us examine the scientific evidence and separate fact from fiction.

GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60. The molecule has a very high affinity for copper and forms the chelate GHK-Cu. 

The peptide as well as its Cu (II) chelate, have anti-inflammatory and tissue remodeling properties. GHK-Cu has been shown to promote skin remodeling, wound healing, and regeneration and has prominent antioxidant and anti-inflammatory effects in in vitro and in vivo studies. In addition, preliminary observations suggest GHK can partially reverse cognitive impairment in aging mice by targeting anti-inflammatory and epigenetic pathways.[3]

Is The GHK-Cu Peptide Supported By Scientific Evidence?

Despite testimonials and anecdotal evidence to the contrary, more scientific research is required to confirm the efficacy of GHK-Cu peptides.

Many investigations into the possible perks of GHK-Cu peptide have revealed that the protein has the ability to control gene expression, promote wound healing, and increase the synthesis of essential elements in the dermal matrix.

More research is needed to fully understand its mechanisms of action and long-term effects when fully integrated into skincare formulations.

Recent discoveries on the actions of the human tripeptide GHK (glycyl-L-histidyl-L-lysine) to reset gene expression of human cells to a more healthy state may open a door to the therapeutic resetting of genes in the elderly. This can be useful as a preventative measure and a complementary treatment for conditions typically associated with aging, such as cancer, Alzheimer’s, chronic obstructive lung disease (COPD), nephropathy, and retinopathy. [4]

GHK-Cu Peptide Near Me

Hormone Replacement Therapy offers the best GHK-Cu peptides near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

1. None Loren Pickart, Vasquez-Soltero JM, Pickart FD, None John Majnarich. GHK, the Human Skin Remodeling Peptide, Induces Anti-Cancer Expression of Numerous Caspase, Growth Regulatory, and DNA Repair Genes. Journal of analytical oncology. 2014;3(2). doi:https://doi.org/10.6000/1927-7229.2014.03.02.2
2. Hostynek JJ, Dreher F, Maibach HI. Human skin penetration of a copper tripeptide in vitro as a function of the skin layer. Inflammation research. 2010;60(1):79-86. doi:https://doi.org/10.1007/s00011-010-0238-9
3. Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging pathobiology and therapeutics. 2020;2(1):58-61. doi:https://doi.org/10.31491/apt.2020.03.014
4. Pickart L, Jessica Michelle Vasquez-Soltero, Margolina A. GHK and DNA: Resetting the Human Genome to Health. BioMed research international. 2014;2014:1-10. doi:https://doi.org/10.1155/2014/151479