Peptides For Weight Loss

How do Peptides Function in the Body?

• Semaglutide: This GLP-1 receptor agonist is approved for both type 2 diabetes (as Ozempic) and obesity (as Wegovy). It stimulates insulin release, improves blood sugar levels, and reduces appetite, leading to weight loss. Typically administered via a once-weekly injection.
• Liraglutide: Another GLP-1 receptor agonist specifically approved for weight loss (as Saxenda). It reduces appetite and helps maintain weight loss for at least a year. Given as a once-daily injection.
• Tirzepatide: Also a GLP-1 receptor agonist used for type 2 diabetes. In clinical trials, varying doses of tirzepatide led to substantial and sustained weight reduction over 72 weeks compared to a placebo.
• AOD 9604: Derived from growth hormone (GH), AOD 9604 promotes lipolysis (fat breakdown) and inhibits lipogenesis (fat accumulation). It utilizes body fat reserves to prevent further accumulation and result in weight loss.
• Amino-1MQ: Known as an anti-obesity drug, Amino-1MQ inhibits an enzyme in cells, speeding up fat metabolism. It also helps reduce blood cholesterol levels, ensuring a healthy lipid profile.
• CJC-1295: Stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Targets adipocytes (fat cells) and promotes fat breakdown. When stacked with Ipamorelin, it offers synergistic benefits for weight loss

Benefits and Side Effects of Weight Loss Peptides

Semaglutide:

• Benefits: Semaglutide is currently one of the most effective weight loss options. It stimulates insulin release, improves blood sugar levels, and reduces appetite. 
• Side Effects: Allergic reactions, hypoglycemia, gastric problems, and dizziness. More serious side effects include thyroid C-cell tumors.

Liraglutide:

• Benefits: Control high blood sugar in people with type 2 diabetes and aids in weight loss.
• Side Effects: Nausea, diarrhea, constipation, indigestion, upper respiratory tract infection, thyroid C-cell tumors.

Tirzepatide:

• Benefits: Blood sugar control (Mounjaro) and weight loss (Zepbound).
• Side Effects: Thyroid C-cell tumors, nausea, diarrhea, decreased appetite, abdominal pain and discomfort, constipation.

AOD 9604:

• Benefits: Promotes lipolysis (fat breakdown) and inhibits lipogenesis (fat accumulation). It utilizes body fat reserves to prevent further accumulation and lead to weight loss.
• Side Effects: Notable side effects include kidney toxicity, pain at the injection site, and possible fatigue and muscle weakness.

CJC-1295:

• Benefits: It increases muscle growth performance, reduces body fat, and increases lean muscle mass. It also improves skin health and sleep quality.
• Side Effects: Injection site reactions, gastric problems, water retention, unstable blood glucose levels, and cancer risk.

Clinical Evidence and Research

Semaglutide

In a 2022 study, researchers compared the weight loss effectiveness of semaglutide and liraglutide when combined with diet and exercise. The findings indicated that semaglutide led to greater weight loss at 68 weeks compared to liraglutide. [1].

Liraglutide

A 2021 study showed that 277 subjects taking 3 mg of liraglutide daily lost 9 pounds (4.1 kg) [2].

Tirzepatide

A study conducted with participants with obesity issues stated that treatment with tirzepatide had an average weight loss of 10%-20% of their body weight after 72 weeks [3].

AOD9604

A report shared the evidence from a 12-week trial that a low dose of AOD9604 helps in weight loss in overweight patients [4].

5-Amino-1MQ

According to research, 5-Amino-1MQ was able to prevent fat accumulation and shrink fat cells, reducing the appearance of fat tissue [5].

CJC-1295

According to an article from Peptide Sciences, the effects of CJC-1295, a synthetic derivative of growth hormone-releasing hormone (GHRH), may enhance fat metabolism and promote muscle growth.

Peptides For Weight Loss

Hormone Replacement Therapy LA offers the best peptides for weight loss near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

1. Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138–150. doi:10.1001/jama.2021.23619
2. Haase CL, Serratore Achenbach MG, Lucrezi G, Jeswani N, Maurer S, Egermann U. Use of Liraglutide 3.0 mg for Weight Management in a Real-World Setting in Switzerland. Obes Facts. 2021;14(5):568-576. doi:10.1159/000518325
3. Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine. 2022;387(3):205-216. doi:https://doi.org/10.1056/nejmoa2206038
4. News Medical. Obesity drug codenamed AOD9604 highly successful in trials. News-Medical. Published December 16, 2004. Accessed February 28, 2024. https://www.news-medical.net/news/2004/12/16/6878.aspx
5. Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60(12):5015–5028.