Wegovy Injection for Weight Loss

Wegovy Injection For Weight Loss - HRT

Wegovy (semaglutide) is approved for adults with weight problems with at least one medical condition, such as high blood pressure, type 2 diabetes, or high cholesterol.

Approved by the FDA, Wegovy works by mimicking a hormone called GLP-1 that targets areas of the brain that regulate appetite and food intake. It helps a person feel full for longer, prompting them to eat less. It also slows stomach emptying to promote fullness. Want to know more about Wegovy injections and their effectiveness for weight loss? Go to our Hormone Replacement Therapy LA website. Need to call us? Call us at 424-283-4273.

What is Wegovy?

Wegovy contains the active drug semaglutide, which belongs to a class of medications called GLP-1 receptor agonists. GLP-1 stands for glucagon-like peptide-1, which is a hormone released naturally in the body after eating [1].

In a clinical study, people taking Wegovy lost 5-20% of their body weight on average over 68 weeks when used along with diet and exercise [2]. Like other weight loss medications, it’s meant to be used along with lifestyle changes.

Wegovy’s Mechanisms of Action for Weight Loss

  • Appetite Regulation: Wegovy targets areas in the brain that regulate appetite and food intake, leading to a reduced sensation of hunger.
  • Insulin Secretion: It promotes the secretion of insulin, which helps lower blood sugar levels after eating.
  • Slows Gastric Emptying: The medication slows down the rate at which the stomach empties its contents, contributing to a feeling of fullness.

Reduces Glucagon Secretion: It also reduces the secretion of glucagon after meals, which helps prevent the liver from producing too much sugar.

How it works

Contact us at +1 424-283-4273 to schedule an in office consult or virtual consult

or Book Online to receive your prescription of Wegovy or other Semaglutide or Trizepatide for weight loss.

  • Virtual Consult with MD & Nutritionist $450
  • 3 Month Supply of the best compounded semaglutide injection  $750 ( Special Pricing) 
  • Follow Ups $250
  • Lose 10 – 20% of body fat safely and effectively
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Efficacy and Benefits of Wegovy Injections

Wegovy has been shown to be quite effective for weight loss in clinical trials, leading to significant reductions in body weight and offering other health benefits. Here are some study results:

Study 1 (1,961 adults):

In a study involving 1,961 adults, it was found that users of Wegovy experienced significant weight loss. On average, they shed 15% of their body weight over a period of 68 weeks. In contrast, those who were given a placebo only lost about 2% of their body weight. Furthermore, 84% of Wegovy users achieved a weight loss of at least 5%, a stark contrast to the 31% in the placebo group.

Study 2 (611 adults with counseling):

In the second study, which included 611 adults receiving counseling, Wegovy users saw an impressive average weight loss of 16% after 68 weeks. In comparison, those given a placebo reported an average weight loss of 6%. Notably, 85% of individuals on Wegovy achieved a minimum weight loss of 5%, which was significantly higher than the 48% who did so with a placebo, demonstrating Wegovy’s substantial impact on weight loss.

Study 3 (902 adults maintaining weight loss):

In the third study of 902 adults who were maintaining their weight loss, those on Wegovy continued to slim down, achieving an additional 8% reduction in body weight over an extended 48 weeks. Conversely, placebo users experienced a weight rebound, regaining 7% of their body weight after discontinuing Wegovy. This suggests that ongoing Wegovy treatment may be necessary to prevent weight regain.

Type 2 Diabetes Patients Study:

Study 4 (1,210 adults with type 2 diabetes):

In a study with 1,210 adults diagnosed with type 2 diabetes, participants using Wegovy lost an average of 10% of their body weight over 68 weeks. Those in the placebo group saw a more modest weight loss of about 3%. Additionally, 67% of the Wegovy group achieved at least a 5% weight loss, which was more than double the 30% success rate seen in the placebo group, underscoring the potential benefits of Wegovy for weight management in diabetic patients.

Adolescent Study:

Adolescent Study (200 participants aged 12 to less than 18 years):

In an adolescent study with 200 young participants aged between 12 and 18 years, Wegovy treatment led to an average BMI reduction of 16% over 68 weeks [3]. In stark contrast, those on a placebo saw their BMI increase by less than 1%. Moreover, approximately 73% of the adolescents using Wegovy successfully lost at least 5% of their body weight, compared to only about 18% of those taking a placebo, indicating a significant benefit of Wegovy in this age group.

Potential Side Effects of Wegovy Injection

Potential Side Effects

  • Nausea and vomiting [4].
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Headache
  • Fatigue
  • Dizziness

Less common side effects may involve:

  • Indigestion
  • Bloating
  • Gas

Serious but rare side effects include:

  • Pancreatitis
  • Gallstones
  • Increased heart rate 
  • Hypoglycemia in type 2 diabetic patients
  • Wegovy is not allowed for patients diagnosed with or who have a family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia Syndrome type 2 (MEN 2).

Patient Eligibility and Considerations

Patient Eligibility:

  • Adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition such as hypertension, type 2 diabetes, or dyslipidemia [5].
  • Patients who have not had success in weight loss or who have plateaued during an initial weight management program focusing on diet, exercise, and lifestyle changes

Additional Considerations:

  • Dosing Schedule: Wegovy is started at a dose of 0.25 mg once a week and gradually increased every four weeks to a maintenance dose, which can be either 1.7 mg or 2.4 mg once a week.
  • Missed Doses: If a dose is missed and the next scheduled dose is more than 2 days away, take the missed dose as soon as possible. If the next dose is less than 2 days away, skip the missed dose and continue with the regular schedule.
  • Administration Tips: It can be taken with or without food. If you need to change the day of the week for your injection, ensure that the last dose was given at least 2 days before.

Comparative Analysis with Other Weight Loss Treatments

Wegovy vs Ozempic

Semaglutide is the key component of Wegovy, functioning as a GLP-1 receptor agonist, a mechanism it shares with Ozempic. Although both medications contain semaglutide, Ozempic is tailored for managing blood sugar levels in type 2 diabetes, not for weight loss. Wegovy stands out with its higher dosage of semaglutide at 2.4 mg, compared to Ozempic’s 1 mg. Studies comparing the two indicate that Wegovy’s higher dose more effectively curbs hunger and reduces calorie intake, leading to almost twice the weight loss seen with Ozempic.

Wegovy vs Saxenda

Saxenda and Wegovy are both weekly injectable GLP-1 receptor agonists used for weight management, but they differ in their active ingredients; Saxenda contains liraglutide, while Wegovy has semaglutide. Clinical trials have shown that Wegovy users typically experience a weight reduction of about 15% from their initial weight after one year, compared to an average of 6% weight loss for those on Saxenda. This data suggests that Wegovy may offer superior weight loss results.

Wegovy vs Orlistat/Xenical

Orlistat, an oral medication taken with meals up to three times daily, operates differently from GLP-1 drugs like Wegovy. It acts in the gastrointestinal tract to inhibit the absorption of some fats from the diet. Although Orlistat is effective for certain individuals, research indicates that only about 10% of users achieve a weight loss of 10% or greater. In comparison, Wegovy has shown that almost 70% of its users can reach or exceed this level of weight loss when used over an extended period.

Cost Considerations and Insurance Coverage

If you have health insurance through your employer or a private provider, you might be eligible to get Wegovy at no cost. Novo Nordisk offers a savings card that can reduce your monthly expenses by up to $225 if your insurance covers the medication.

For those without Wegovy insurance coverage, the cost can range from $1,350 to $1,800 for a 28-day supply. However, Novo Nordisk provides a savings card that could lower the cost by up to $500. With this card, eligible individuals may pay nothing for their monthly supply for up to 12 refills. It’s always best to check with your insurance provider and Novo Nordisk for the most accurate and current information regarding coverage and costs.

Wegovy Injections for Weight Loss Near Me

Weight Loss Clinic LA offers the best Wegovy Injections near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

  1. Singh G, Krauthamer M, Bjalme-Evans M. Wegovy (semaglutide): a new weight loss drug for chronic weight management. J Investig Med. 2022;70(1):5-13. doi:10.1136/jim-2021-001952
  2. Ghusn W, De la Rosa A, Sacoto D, et al. Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity. JAMA Netw Open. 2022;5(9):e2231982. Published 2022 Sep 1. doi:10.1001/jamanetworkopen.2022.31982
  3. Wegovy | European Medicines Agency. Europa.eu. Published March 10, 2022. Accessed December 7, 2023. https://www.ema.europa.eu/en/medicines/human/EPAR/wegovy
  4. Singh G, Krauthamer M, Bjalme-Evans M. Wegovy (semaglutide): a new weight loss drug for chronic weight management. J Investig Med. 2022;70(1):5-13. doi:10.1136/jim-2021-001952
  5. Committee for Medicinal Products for Human Use (CHMP) Assessment Report Wegovy.; 2021. https://www.ema.europa.eu/en/documents/assessment-report/wegovy-epar-public-assessment-report_en.pdf

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