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Hormone for Weight Loss

Hormone for Weight Loss - HRT

Like many other functions, our body’s hormones also help in weight loss. These hormones have different ways of promoting, such as controlling hunger, metabolic rate, glucose regulation, etc. If your body is resistant to these naturally occurring hormones, this may cause weight gain.

So, to lose weight, you need to understand the role of the different types of hormones and types of hormone therapy needed to facilitate your weight loss. Speaking of hormone therapy, if you’re interested, you can check out Hormone Replacement Therapy LA for more information and treatment options.

The role of hormones in weight loss

Hormones help control appetite and satiety signals, metabolic rate, glucose regulation, and distribution of fat tissue. Getting a better understanding of how these hormones work can provide insights into why losing weight can be such an uphill battle.

Some of the main hormones that impact weight loss efforts are:


This hormone is essential for shuttling glucose out of the bloodstream and into cells for energy. However, chronically high insulin levels promote fat storage, particularly around the belly. Insulin resistance is also tied to obesity and difficulty losing weight [1].


Produced by fat cells, leptin suppresses appetite and communicates satiety to the brain after eating. People struggling with obesity often develop leptin resistance, undermining the hormone signals of fullness and continuing to drive overeating [2].


Ghrelin communicates hunger signals, triggering us to seek out and consume food. Dieters struggling with cravings often have excessive ghrelin production, making sticking to portion-controlled meals a constant struggle [3].


This primary stress hormone causes fat storage around the midsection when elevated over long periods of time. Chronically high cortisol disrupts sleep, metabolic rate, and blood sugar regulation – all factors that sabotage weight loss [4].

How does insulin affect weight?

Glucose Regulation

Insulin helps regulate blood sugar levels by facilitating the uptake of glucose (sugar) from the bloodstream into cells. When you eat, your body releases insulin to manage the influx of glucose. 

Insulin promotes the storage of excess glucose as glycogen in the liver and muscles. When these glycogen stores are full, any additional glucose is converted into fat and stored in adipose tissue (body fat). This fat storage can contribute to weight gain.

Insulin inhibits the breakdown of stored fat (lipolysis). When insulin levels are high (such as after a high-carbohydrate meal), your body prioritizes using glucose for energy rather than tapping into fat stores. Consequently, weight loss becomes more challenging.

Insulin Resistance and Weight Gain

In conditions like insulin resistance (common in type 2 diabetes and obesity), cells become less responsive to insulin. As a result, the pancreas produces more insulin to compensate. Elevated insulin levels can lead to weight gain due to increased fat storage. Insulin resistance is associated with the accumulation of visceral fat (fat around organs), which is linked to health risks like heart disease and metabolic syndrome.

Carbohydrate Intake and Insulin Release

Consuming carbohydrates (especially refined sugars and starches) triggers insulin release. High-carb diets can lead to frequent insulin spikes, potentially promoting fat storage. Some weight loss diets (e.g., low-carb or ketogenic diets) aim to reduce insulin secretion by limiting carb intake. This may enhance fat breakdown and weight loss.

How it works

Contact us at +1 424-283-4273 to schedule an in office consult or virtual consult

or Book Online to receive your prescription of Wegovy or other Semaglutide or Trizepatide for weight loss.

  • Virtual Consult with MD & Nutritionist $450
  • 3 Month Supply of the best compounded semaglutide injection  $750 ( Special Pricing) 
  • Follow Ups $250
  • Lose 10 – 20% of body fat safely and effectively

Balancing Insulin Levels for Weight Management

  • Choose Whole Foods: Opt for whole grains, fruits, vegetables, and lean proteins. These foods have a gentler impact on insulin levels.
  • Physical Activity: Regular exercise improves insulin sensitivity, allowing cells to use glucose effectively.
  • Meal Timing: Spreading meals throughout the day can help maintain stable insulin levels.
  • Avoid Overeating: Excessive calorie intake can lead to insulin spikes and weight gain.

What role do thyroid hormones play in metabolism and weight?

Thyroid hormones significantly influence both metabolism and weight. Let’s explore their impact:

Metabolism and Thyroid Hormones

  • Your metabolism involves processes that break down food and convert it into energy for your body to function.
  • Basal Metabolic Rate (BMR): This represents the calories your body burns at rest. It determines how quickly (or slowly) you use calories.
  • Thyroid hormones work closely with your hypothalamus (a brain area) to maintain energy balance after eating and calorie utilization.

Hypothyroidism (Too Little Thyroid Hormone)

When your thyroid produces insufficient hormones (hypothyroidism):

  • Metabolism Slows Down: Your body burns fewer calories, leading to weight gain.
  • Appetite Increases: You may eat more, further contributing to weight gain.

Hyperthyroidism (Excess Thyroid Hormone)

When your thyroid produces too many hormones (hyperthyroidism):

  • Overdrive Metabolism: Your body burns more calories even at rest, resulting in weight loss.

Complex Interplay

Thyroid hormones don’t act alone; they work with other hormones, proteins, and chemicals. Research shows varying conclusions regarding thyroid hormones and weight gain:

  • TSH (Thyroid Stimulating Hormone): Levels are often elevated in obesity.
  • Free T3 (triiodothyronine): Levels tend to be high.
  • Free T4 (thyroxine): Levels may be low or normal.

Individual Variability

  • Thyroid function varies among individuals.
  • Consult a healthcare professional for personalized guidance.

What Is Hormone Replacement Therapy (HRT)?

HRT, also known as menopausal hormone therapy or estrogen replacement therapy, alleviates menopause symptoms. The main hormones used in HRT are estrogen and progesterone.

It aims to restore hormonal balance and manage symptoms like hot flashes, mood changes, and weight fluctuations.

Types Of Hormone Therapy For Weight Loss

Human Chorionic Gonadotropin (hCG) Injections

hCG mimics the hormone produced during pregnancy, signaling the body to tap into abnormal fat stores. The hCG protocol combines very low-calorie dieting with hCG injections or sublingual tablets. Done under medical supervision for 3-6 weeks, patients can experience rapid weight loss and reduced hunger.

Thyroid Hormone Therapy

Since thyroid hormones T3 and T4 strongly stimulate metabolism, deficiencies slow efforts to burn fat. Correcting low thyroid function with bioidentical hormones like levothyroxine or liothyronine can raise metabolic rate while improving energy, body temperature regulation, and more.

Testosterone Replacement Therapy (TRT)

Low testosterone in both men and women is linked to increased belly fat and difficulty building lean muscle. Testosterone therapy helps boost muscle growth, supporting an efficient metabolism while regulating the distribution of fat tissue.

Bioidentical Hormone Therapy

Bioidentical hormones have the same molecular structure as hormones produced in the body. Custom-compounded treatment plans address deficiencies in hormones like DHEA, melatonin, GH, and more. Restoring balance in the interconnected hormone network enhances overall metabolic function.

Benefits and Risks of HRT


  • Improved menopause symptoms.
  • Potential weight management due to hormonal balance.


  • Increased risk of blood clots
  • Stroke
  • Breast cancer (especially with long-term use)

Ozempic, Wegovy, and Mounjaro For Weight Loss

Ozempic, Wegovy, and Mounjaro For Weight Loss


Ozempic mimics the effects of GLP-1, an appetite-regulating hormone. By activating GLP-1 receptors, Ozempic suppresses appetite and promotes feelings of fullness and satiety. This typically leads to reduced food intake and calorie restriction. Ozempic also slows the rate at which food empties from the stomach into the intestines. This prolongs the feeling of fullness after eating, further curbing appetite and calorie intake.

Ozempic can lower blood sugar and improve how the body handles insulin. This may have secondary effects on weight regulation. Poor blood sugar control is linked to increased calorie intake and fat storage.

Research indicates that pairing Semaglutide treatment with lifestyle modification leads to greater weight reduction outcomes.


Wegovy is an injectable prescription medication for chronic weight management in obese or significantly overweight adults who cannot lose sufficient weight through diet, exercise, and other lifestyle interventions alone. Its active ingredient, semaglutide, belongs to the GLP-1 receptor agonist class of drugs that mimic the appetite-regulating hormone GLP-1 in the brain.

By activating specific receptors, Wegovy triggers increased feelings of fullness and reduced hunger. These effects lead to decreasing caloric intake and subsequent weight reduction. Its mechanisms provide sustained appetite control rather than short-term dietary compliance.

Due to its effectiveness, the FDA has approved Wegovy for chronic weight management in adults with obesity or overweight and at least one weight-related condition. 


Mounjaro is a new diabetes drug that is quickly gaining attention for its potential to help people with obesity lose weight 1. It works by targeting two hormones: GLP-1, a hormone released from your digestive tract that helps lower blood sugar and promotes a feeling of fullness, and glucose-dependent insulinotropic polypeptide, a hormone that stimulates the release of insulin.

Mounjaro helps with weight loss by decreasing food intake and slowing down how fast food travels through your digestive tract, which may help you feel fuller for a longer period and reduce how much food you eat.

In one study of more than 2,500 adults with obesity, people taking 5 milligrams of Mounjaro for 72 weeks (about a year and a half) lost 15% of their body weight on average [5].

Alternatives to Hormone Replacement Therapy (HRT)

  • Focus on whole foods and manage portion sizes.
  • Boosts metabolism and insulin sensitivity with regular exercise.
  • Try managing your stress by meditation, practicing deep breathing techniques, etc.

Hormone for Weight Loss Near Me

Hormone Replacement Therapy LA offers the best medical weight loss program near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.


  1. Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. Insulin resistance: Review of the underlying molecular mechanisms. J Cell Physiol. 2019 Jun;234(6):8152-8161. doi: 10.1002/jcp.27603. Epub 2018 Oct 14. PMID: 30317615.
  2. Izquierdo AG, Crujeiras AB, Casanueva FF, Carreira MC. Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? Nutrients. 2019; 11(11):2704.
  3. Makris MC, Alexandrou A, Papatsoutsos EG, Malietzis G, Tsilimigras DI, Guerron AD, Moris D. Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal. In Vivo. 2017 Nov-Dec;31(6):1047-1050. doi: 10.21873/invivo.11168. PMID: 29102924; PMCID: PMC5756630.
  4. van der Valk ES, Savas M, van Rossum EFC. Stress and Obesity: Are There More Susceptible Individuals? Curr Obes Rep. 2018 Jun;7(2):193-203. doi: 10.1007/s13679-018-0306-y. PMID: 29663153; PMCID: PMC5958156.
  5. Jastreboff AM, Aronne LJ, Ahmad N, et al. Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine. 2022;387(3):205-216. doi:

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