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Peptides For Skin

Peptides For Skin - HRT

Do you know? It’s been proven that peptides work wonders for the skin. At Hormone Replacement Therapy LA, we use peptide treatments to diminish fine lines and wrinkles and much more.

Peptides, short chains of amino acids, are the building blocks of key skin proteins, such as collagen and elastin. They are also naturally present in the skin and are included in many skincare products.

Peptides For Skin

  • Epitalon: Research has demonstrated that this peptide stimulates skin fibroblasts, which are cells in charge of preserving and mending the extracellular matrix that gives our skin its strength.
  • GHK-Cu Fundamentals: GHK-Cu is a peptide that promotes the formation of collagen, which can result in a gain in muscle mass and a suppleness of the skin.
  • Argireline: This peptide helps lessen the face muscles’ recurrent contractions, which may eventually assist to lessen the fine lines brought on by specific facial expressions.
  • Matrixyl: Matrixyl is a peptide that promotes the skin’s synthesis of hyaluronic acid, collagen, and elastin—all vital elements for preserving the skin’s firmness and suppleness.
  • P21: P21 is a synthetic peptide that has been researched for its possible application in extending life, avoiding age-related illnesses, and improving general health and well-being.
  • L-glutathione: Smoking, pollution, and the sun can all cause free radical damage to the skin. Glutathione is an antioxidant that can help stop this damage. Glutathione, both oral and topical, may help brighten dark spots brought on by the sun, drugs, and illnesses.
  • FOXO4-DRI: Research has been conducted on the peptide FOXO4-DRI to see whether it can increase longevity, prevent age-related disorders, or improve general health and wellness.
  • Tripeptide-29: This peptide aids in the skin’s production of collagen. It makes skin seem and feel plumper, more elastic, and hydrated while also helping to soften the appearance of fine wrinkles.
  • NAD+: By supplying energy, repairing DNA, and strengthening skin cells against damage and stress, NAD+ is essential for preserving the health of the skin.

How it works

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What advantages come with peptide use in skincare products?

  • Encourage Collagen Production: Since collagen is composed of three polypeptide chains, you can encourage your skin to produce collagen by using peptides. More collagen can make skin appear firmer and younger.
  • Enhance Skin Barrier: The body’s first line of defense against germs, UV radiation, pollutants, and other toxins is the skin barrier, which peptides assist in strengthening.
  • Reduce Wrinkles: Collagen helps make lips and skin more plump. Wrinkles and fine lines will be less noticeable in skin that is plumper and firmer.
  • More Skin Elasticity: In addition to collagen, peptides also make up elastin fibers, another type of protein. These fibers make skin look firmer and tauter.
  • Ease Inflammation: Peptides can help ease inflammation, repair damaged skin, and even out skin tone.
  • Clear Breakouts: Some peptides are antimicrobial, meaning they can kill bacteria that cause acne.

What advantages come with peptide use in skincare products

Are peptides suitable for all skin types?

Yes, peptides are generally considered to be non-irritating and can be well-tolerated by all skin types, including sensitive skin. They are great for all skin types, especially for those who are dry to mature and notice increased fine lines and wrinkles and a loss in firmness. 

Are there any peptides made especially to target hyperpigmentation or dark spots?

Yes, there are peptides called inhibitor peptides that can be quite helpful in treating skin diseases that cause excessive pigmentation. The pigment known as melanin, which determines the color of your skin, hair, and eyes, can be inhibited by these peptides. 

Do peptides penetrate deeper layers of the skin compared to other ingredients like hyaluronic acid or glycolic acid?

Yes, peptides are known to penetrate the outer layer of the skin and sink in more deeply. They are essentially smaller versions of proteins, typically comprising 2–50 amino acids, which are the necessary building blocks of proteins. Because they are smaller, peptides are easier for the body to absorb than proteins and can more easily penetrate the skin and intestines, which helps them enter the bloodstream more quickly.

On the other hand, hyaluronic acid is a carbohydrate molecule that is naturally found in the skin. It helps to keep the skin hydrated and plump and is a key component of healthy skin. Hyaluronic acid is known for its ability to attract and retain moisture.

As for glycolic acid, it is a type of alpha-hydroxy acid (AHA) that is often used in skincare products for its exfoliating properties. It works on the surface of the skin, helping to remove dead skin cells and reveal the newer, brighter layers underneath.

Clinical studies supporting the effectiveness of peptides in skincare

A 14-week study of a peptide therapy serum targeted to repair aging face skin found considerable improvement in facial and eye lines/wrinkles at rest, as well as maximum smile by week 14 [1].

Another study showed that some peptides have the ability to destroy acne-causing bacteria because of their antimicrobial properties [2].

Based on different intracellular mechanisms, bioactive peptides have been shown in numerous in vitro/in vivo studies and clinical trials to be effective in improving skin appearance in topical applications and oral administration. These effects include improved skin whitening and moisturizing and a reduction in skin aging [3].

After 12 weeks of use, an IRB-approved clinical trial showing that LTPS was beneficial in alleviating expression lines, wrinkles, and skin health was completed. The study was randomized, double-blind, placebo-controlled [4].

Peptides For Skin

Hormone Replacement Therapy LA offers the best peptides for skin near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.


  1. Draelos ZD, Kononov T, Fox T. An Open Label Clinical Trial of a Peptide Treatment Serum and Supporting Regimen Designed to Improve the Appearance of Aging Facial Skin. J Drugs Dermatol. 2016 Sep 1;15(9):1100-6. PMID: 27602972.
  2. Lei J, Sun L, Huang S, et al. The antimicrobial peptides and their potential clinical applications. Am J Transl Res. 2019;11(7):3919-3931. Published 2019 Jul 15.
  3. Ngoc LTN, Moon J-Y, Lee Y-C. Insights into Bioactive Peptides in Cosmetics. Cosmetics. 2023; 10(4):111.
  4. Nguyen TQ, Zahr AS, Kononov T, Ablon G. A Randomized, Double-blind, Placebo-controlled Clinical Study Investigating the Efficacy and Tolerability of a Peptide Serum Targeting Expression Lines. J Clin Aesthet Dermatol. 2021;14(5):14-21.

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