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Semaglutide Peptide

Semaglutide Peptide - HRT

Semaglutide is an artificial analogue of glucagon-like peptide-1 (GLP-1). GLP-1 is a peptide hormone produced by the body that has thirty amino acids. It helps stimulate insulin gene transcription, hence improving insulin production, lowering blood sugar levels, and protecting pancreatic beta cells. 

It is mainly used to treat type 2 diabetes, while it has also demonstrated promise in the control of obesity. You can inject semaglutide subcutaneously or take it orally. Learn more about Semaglutide Peptide from us at Hormone Replacement Therapy LA.

Which semaglutide is best for weight loss?

Wegovy, or semaglutide 2.4, is the only weight-loss medicine approved by the US Food and Drug Administration (FDA) for weight management. Another brand of semaglutide, Ozempic, is mostly used to treat type 2 diabetes, but it can also be taken off-label to help overweight patients lose weight and alleviate conditions like high blood pressure. 

What is semaglutide peptide good for?

Diabetes type 2: 

Semaglutide helps patients with type 2 diabetes better control their blood sugar levels. It mimics the function of GLP-1, a hormone that is present in the body naturally and aids with blood glucose regulation.

Weight Loss:

In individuals who are obese or overweight, semaglutide is also used to regulate weight. It modifies food preference by reducing the desire for high-fat and high-glycemic foods, reduces cravings, suppresses appetite, and encourages fullness by slowing digestion. 

Cardiovascular Health:

In patients with type 2 diabetes who also have heart disease, semaglutide may lower their chance of experiencing future cardiovascular events, such as a heart attack or stroke.

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How does Semaglutide peptide differ from other medications used for similar conditions?

Polycystic Ovary Syndrome (PCOS): 

Insulin resistance is a typical sign of PCOS in individuals, and it can result in obesity. Semaglutide can assist in controlling weight and PCOS symptoms like acne and irregular periods. It helps in the management of PCOS because of its capacity to reduce insulin resistance.

Metabolic syndrome: 

Also referred to as insulin resistance syndrome, this group of illnesses raises the risk of heart attacks, strokes, and diabetes. Semaglutide lowers the risk of diabetes and heart disease, which helps with weight loss and improves metabolic syndrome.

Certain Cancers:

Scientists are examining the relationship between insulin resistance and particular diseases (including endometrial, breast, and colon cancer). The possibility for semaglutide to increase insulin resistance may lower the risk of some cancer types. 

Alzheimer’s Disease Prevention:

A study discovered a link between type 2 diabetes and dementia in all its manifestations. Because of its effect on insulin resistance, semalglutide may be used as a prophylactic medication for Alzheimer’s disease.

Types of Semaglutide

Types of Semaglutide - HRT

Ozempic (Semaglutide):

  • Semaglutide, commonly referred to as Ozempic, is a prescription medication that is used in conjunction with diet and exercise to treat type 2 diabetes. 
  • It reduces the risk of heart attacks and strokes and aids in better blood sugar regulation. 
  • Ozempic is not insulin and is not used to treat type 1 diabetes.
  • FDA-approved for the treatment of type 2 diabetes and to help those who have both conditions avoid major cardiovascular events
  • Off-label use for weight loss in overweight patients may also be utilized to improve health outcomes, such as high blood pressure.

Wegovy (Semaglutide):

  • Another kind of semaglutide is wegovy.
  • The FDA has given it approval especially for weight loss.
  • It is an injectable medicine, just like Ozempic.
  • Wegovy promotes weight loss and decreases hunger, which aids in long-term weight management.

Rybelsus (Semaglutide):

  • Rybelsus is a brand of semaglutide oral tablet.
  • Along with diet and exercise, it is also used to reduce blood sugar levels in adults with type 2 diabetes mellitus.

Researched backed evidences

The diabetic drug oral semaglutide has demonstrated remarkable effects in reducing weight and HbA1c, a gauge of average blood sugar levels over time. Oral semaglutide is superior to other popular diabetic drugs such as sitagliptin, empagliflozin, and liraglutide in lowering weight and HbA1c levels [1].

The diabetic drug oral semaglutide has demonstrated remarkable effects in reducing weight and HbA1c, a gauge of average blood sugar levels over time. Oral semaglutide is superior to other popular diabetic drugs such as sitagliptin, empagliflozin, and liraglutide in lowering weight and HbA1c levels [2].

Trials showed that Ozempic, when compared to a fake treatment, helped lower blood sugar levels in patients with type 2 diabetes. It was generally well-tolerated, and most patients experienced improvements in their condition [3].

In a clinical trial, when Wegovy was administered in conjunction with diet and exercise, participants lost an average of 5-20% of their body weight over 68 weeks [4].

References:

  1. Kalra S, Das S, Zargar AH. A Review of Oral Semaglutide Available Evidence: A New Era of Management of Diabetes with Peptide in a Pill Form. Indian J Endocrinol Metab. 2022 Mar-Apr;26(2):98-105. doi: 10.4103/ijem.ijem_522_21. Epub 2022 Jun 6. PMID: 35873937; PMCID: PMC9302409.
  2. Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138–150. doi:10.1001/jama.2021.23619
  3. HIGHLIGHTS of PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209637s003lbl.pdf
  4. Ghusn W, De la Rosa A, Sacoto D, et al. Weight Loss Outcomes Associated With Semaglutide Treatment for Patients With Overweight or Obesity. JAMA Netw Open. 2022;5(9):e2231982. Published 2022 Sep 1. doi:10.1001/jamanetworkopen.2022.31982

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