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Symptoms Of Hormone Pellets Wearing Off: Time For Another Therapy Session

Symptoms Of Hormone Pellets

Yesterday, a patient came to me, complaining about his depression, weight gain, and grumpy mood. He had hormone pellet therapy half a year ago, and now all the symptoms he had prior to placing the pellet had come back.

Hormone pellets are an alternative to oral medications and creams and can help in he balancing of your estrogen or testosterone level. But they are not permanent. Within 3 to 6 months, your pellets will dissolve, and you will require replacement.

Depression, mood swings, fluctuating weight, etc., are the symptoms of hormone pellets wearing off. If you want insight, I recommend you read the following article to the end.

What Are Hormone Pellets? A Brief Overview Of Hormone Pellet Therapy

Do you know why experts call hormones chemical messengers? Yes, these agents run around in the bloodstream and send signals to tissue and organs to do a particular task. Thanks to them, you get a fully functional body.

What happens if your body lacks a hormone or experiences an imbalance? Of course, your body starts acting abnormal, a drop in estrogen levels or testosterone levels drives away your sexual desire. Similarly, fatigue, depression, weight gain, etc., result from testosterone, estrogen and hormone imbalances.

There are many ways your body can get a hormone imbalance. The reasons can vary from physical problems to just the aging process. However, aging in general is the primary cause of our hormone levels decreasing. Men’s testosterone levels are the highest during their 20’s and steadily decrease up to the age of 40. There is more of a rapid decline in testosterone levels after the age of 40. Women tend to reach menopause at the age of 50 but some can go into early menopause earlier. Women’s ovaries stop the production of testosterone, estrogen and progesterone during menopause and as a result there are hormone imbalances. These hormone imbalances can cause hot flashes, insomnia, decrease in mood and energy and other symptoms.

What should you do in such a situation or if you are experiencing these symptoms? Of course, you should go to a doctor and discuss these symptoms and have a laboratory workup to evaluate your hormone levels and get on hormone replacement. Hormone replacement therapy has many benefits and  is the most effective way to replace your hormone imbalances and feel normal again. As mentioned, there are gels, creams, oral medications, triturate (sublingual dissolving hormones) and pellets. Hormone pellet therapy has gained traction as people do not need to worry about taking or applying their hormones on a daily bases.

Hormone pellets are tiny, just about the size of a rice grain, and contain bio-identical hormones. The implant of this hormone reservoir under the skin allows a steady and consistent flow of hormones over several months. Eventually, the pellets dissolve and leave no trace or need for removal.

The compounds of these pellets, estradiol, progestrone or testosterone, come from organic plants, which are safe for human bodies. Not only that, they have the exact molecular structure of the hormones working in your body. So, no harm alert.

If you pull the string, the history of hormone pellet therapy will take you back to the 1930s. The sessions were quite popular during those years but took a hit in the 50s and 60s. Fortunately, the therapy session has gained a lost reputation and is now well-recognized worldwide.

Symptoms Of Hormone Pellets Wearing Off

The inserted hormone pellets serve you for a limited time. Your doctor will provide you with the estimated period of the pellet efficiency and all detail before the implantation.

With the passing months, the pellets start wearing off. Once the hormone grain is gone, your hormone level will drop. 

On average, hormone pellets last for 3 – 4 months in women and around 6 months in men. The lasting period depends on the user’s metabolism and activity level.

See, your body extracts the exact amount of hormones it requires from the pellet. If you are more active or have a fast metabolism, the lifespan of this supplement will decrease.

Once the pellet loses its charm, you will notice several symptoms of the low hormone. Such as,

  • Low libido
  • Fatigue 
  • Sexual dysfunction
  • Depression 
  • Grumpy and irritated mood
  • Mood swing 
  • Muscle loss
  • Hot flashes
  • Night sweat
  • Vaginal dryness for women
  • Headache 
  • Low concentration
  • Trouble sleeping 
  • Fluctuating weight, etc.

Most hormone pellet therapies focus on estrogen, progestrone and testosterone. Women after menopause go for hormone therapy to balance their estrogen levels in the body. Similarly, a testosterone pellet is used to increase muscle mass, improve sexual dysfunction, assist in weight gain, and improve mood or depression in men. Besides these benefits, the grain hormone reservoirs also aid in maintaining heart and bone health.

So, once the pellets wear off, the patients experience the previous signs of low hormones. In such cases, they can return to their practitioner and apply for another therapy session.

BioTe Pellets Wearing Off

BioTe pellets, the cylindrical supplements, are widely used as the primary component in bio-identical hormone replacement therapy. These pellets are safe and provide the exact dosage of the hormone after insertion.

People often prefer BioTe pellets therapy over any other brand of hormone replacement therapy. Thanks to the efficient and effective service BioTe provides with the minimum risk.

While manufacturing, the brand pushes enough hormones the grain-size pellets can carry. If you try redesigning the supplements at this stage, the insertion will become problematic or lose effectiveness.

Every day while releasing hormones, these pellets dissolve little by little. After 3 to 4 months, the supplements wear off completely.

BioTe wearing off brings back your old symptoms of low hormones. Hot flashes, night sweats, dry vagina, mood swings, low libido, etc., are common symptoms of hormone pellets wearing off for women. On the other hand, the males experience muscle loss, depression, low sex drive, fatigue, etc., in such conditions.

BioTe pellet hormone therapy and pellet therapy in general are safe but can come with side effects and some drawbacks. But, returning to the pellets will be a relief for most patients. 

Side Effects Of Hormone Pellets In Females And Males

Hormone pellets are bio-identical and hence, considered safe. However, you can not completely ignore the possibility of a few side effects of these grain-size supplements. The after-pellet effect might vary depending on gender and physique.

Here are the probable side effects of hormones pellet therapy,

Insertion Discomfort

Only professionals are allowed to offer hormone pellet therapy to patients. So, there is decrease risk in the insertion procedure. However, in a few cases, patients might experience bleeding under the skin, infection, or transient discomfort.

The Gluteal area is perfect for pellet insertion, and it is not uncommon to feel tenderness in those areas for a few weeks. Resting, avoiding high-strength activity, and lower body exercises will soon heal the pain.

Digestive Issues

The inserted hormone pellets are new to your system. Of course, it will take a few days for your body to adjust its balance. In the meantime, you might experience minor digestive changes and related issues. Such as,

  • Diarrhea 
  • Constipation
  • Nausea 
  • Indigestion
  • Gastritis, etc.

These symptoms usually go away within a few weeks and are not concerning but please contact your provider to discuss any symptoms that you may be experiencing.

Breast Cancer

HRT can increase the risk of breast cancer returning if you have had a history of breast cancer. Based on the results of a study called the The Women’s Health Initiative there is an increase risk of breast cancer with hormone replacement therapy. However, many physicians believe that the good metabolite of estrogen called estradiol carries less risk of breast cancer and the benefits of HRT outweigh the risks of therapy.

Cardiovascular Disease

Older women on hormone pellets therapy have an increased risk of cardiovascular diseases. But, of course, not all women.

The chance is higher for those who start hormone therapy in the 60s and continue taking estrogen and progesterone. For these reasons, professionals suggest taking this therapy early, within a few years of menopause.

Venous Thrombosis

Another risk of hormone pellet therapy is venous thrombosis—patients with this condition experience vein blockage due to blood clots. Venous thrombosis can be severe and the risk of venous thrombosis occurring is the highest during the first year of treatment. The risk of venous thrombosis is increased with obesity, cancer, and surgery.

Change In Appetite

Hormone imbalance leads to weight fluctuation. You might be gaining or losing weight without changing your diet. As the hormones harmonize with the pellets, you can return to being healthy.

You will notice a difference in your appetite after the insertion of pellets. In the majority of cases, the change is beneficial for you.

Pros And Cons Of Hormone Pellets

Hormone pellet therapy has a few minor drawbacks, and there is no denial. Then why should you still go for this procedure instead of other hormone treatments or oral meds?

Symptoms Of Hormone Pellets Wearing Off

Weigh the pros and cons of this therapy and decide on your own,

Advantages Of Hormone Pellet Therapy

Easy And Risk-Free Implant: Taking medicines every day is a hassle. You keep forgetting the dosage if you are in your 40s or 50s. Hormone pellets are far more compatible and effective, considering the situation. One-time implant and you are fit to go for up to 6 months.

Appreciable Consistency: The pills and creams work in the hormonal imbalance but give you a roller coaster effect. When you take the medications, your hormone level will be the highest, which drops as time goes by.

Now compare the effect to the pellets. These cylindrical supplements release a steady and consistent flow of hormones. So you feel healthy and in control all the time.

Forgetting Is Not An Option: It never happens that I will not miss my course pills or injection at least one day. I am sure the same happens to you too. Sticking with pellets has no risk of forgetting as the supplements are already inside you and serving consistently.

Showering With Success: Have you ever seen the success rate of hormone pellet therapy? It is 95%. On the other hand, the satisfaction rate for creams and gels is 75% and 62%, respectively.

Drawbacks Of Hormone Pellet Therapy

Fear Of Implant: Many patients avoid pellet therapy because of the minor surgery procedure. Though the operation is risk-free and painless, the chances of infection or bleeding are minimum.

Side Effects: Hormone pellet therapy has a few minor side effects. It takes a few weeks to recover and return to active life completely after the surgery.

Non-Removable Pellets: The hormone pellets are non-removable, which increases the risk of over-treatment. Make sure your practitioner is highly trained and knows what he is doing.

Costly: Compared to other hormone therapies, pellet insertion is expensive. But considering the effectiveness and service, the price is quite fair.


The symptoms of hormone pellets wearing off are indications of a renewal session. While these therapies are effective and work on point, they can be expensive. Keep your health condition in mind by weighing all the pros and cons before choosing any hormonal therapy.

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