Symptoms Of Hormone Pellets Wearing Off: Time For Another Therapy Session

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Yesterday, a patient came to me nagging me about his depression, weight loss, and grumpy mood. He had hormone pellet therapy half a year ago, and now here he was, again on the old page.


See, hormone pellets are excellent ways to balance your estrogen or testosterone level. But they are not permanent. Within 3 to 6 months, your pellets will dissolve, and you will require replacement.


Depression, mood swings, fluctuating weight, etc., are the symptoms of hormone pellets wearing off. If you want an insight, I recommend you read the following article to the end.


What Are Hormone Pellets? A Brief Overview Of Hormone Pellet Therapy


Do you know why experts call hormones the chemical messengers? Yes, these agents run around in the bloodstream and signal a specific cell to do a particular task. Thanks to them, you get a fully functional body.


What happens if your body lacks a hormone or experiences an imbalance? Of course, your body starts acting weird for example, a drop in the estrogen level drives away your sexual desire. Similarly, fatigue, depression, weight gain, etc., are also the result of hormone imbalance.


What would you do in such conditions? Of course, you would go to a doctor and take meds. Or, you can explore the more effective and ancient science to end your sufferings. Yes, I am referring to hormone pellets therapy.


Hormone pellets are tiny, just about the size of a rice grain, and contain bio-identical hormones. The implant of this hormone reservoir under the skin allows a steady and consistent flow of hormones over several months. Eventually, the pellets get dissolved and leave no trace or need of removal.


The compounds of these pellets, estradiol or testosterone, come from organic plants, which are safe for human bodies. Not only that, they have the exact molecular structure of the hormones working in your body. So, no harm alert.


If you pull the string, the history of hormone pellet therapy will take you back to the 1930s. The sessions were quite popular during those years but took a hit in the 50s and 60s. Fortunately, the therapy session has gained the lost reputation and is now well-recognized worldwide.


Symptoms Of Hormone Pellets Wearing Off


The inserted hormone pellets serve you for a limited time. Your doctor will provide you with the estimated period of the pellet efficiency and all detail before the implantation.


With the passing months, the pellets start wearing off. Once the hormone grain is gone, your hormone level in the body will drop. 


On average, hormone pellets last for 3 – 4 months in women and around 6 months in men. The lasting period depends on the user’s metabolism and activity level.


See, your body extracts the exact amount of hormones it requires from the pellet. If you are more active or have a fast metabolism, the lifespan of this supplement will decrease.


Once the pellet starts losing its charm, you will notice several symptoms of the low hormone. Such as,


  • Low libido
  • Fatigue 
  • Sexual dysfunction
  • Depression 
  • Grumpy and irritated mood
  • Mood swing 
  • Muscle loss
  • Hot flashes
  • Night sweat
  • Vaginal dryness for women
  • Headache 
  • Low concentration
  • Trouble sleeping 
  • Fluctuating weight, etc.


Most hormone pellet therapies focus on estrogen and testosterone. Women after menopause go for hormone therapy to balance their estrogen flow in the body. Similarly, a testosterone pellet is a must to get rid of muscle loss, sexual dysfunction, and depression for men. Besides these benefits, the grain hormone reservoirs also aid in maintaining heart and bone health.


So, once the pellets wear off, the patients experience the previous signs of the low hormone. In such cases, they can go back to their practitioner and apply for another therapy session.


BioTe Pellets Wearing Off


BioTe pellets, the cylindrical supplements, have a wide use as the primary component in bio-identical hormone replacement therapy. These pellets are safe and provide the exact dosage of the hormone after insertion.


People often prefer BioTe pellets therapy over any other brand of hormone replacement therapy. Thanks to the efficient and effective service BioTe provides with the minimum risk.


While manufacturing, the brand pushes enough hormones the grain size pellets can carry. If you try redesigning the supplements at this stage, the insertion will become problematic or lose effectiveness.


Every day while releasing hormones, these pellets dissolve little by little. After 3 to 4 months, the supplements wear off completely.


BioTe wearing off brings back your old symptoms of low hormones. Hot flashes, night sweats, dry vagina, mood swings, low libido, etc., are common symptoms of hormone pellets wearing off for women. On the other hand, the males experience muscle loss, depression, low sex drive, fatigue, etc., in such conditions.


BioTe pellet hormone therapy has no significant drawbacks. Hence, returning to the pellets will be a relief for most patients. 


Side Effects Of Hormone Pellets In Females And Males


Hormone pellets are bio-identical and hence, considered safe. However, you can not completely ignore the possibility of a few side effects of these grain size supplements. The after pellet effect might vary depending on the gender and physique.


Here are the probable side effects of hormones pellet therapy,


Insertion Discomfort


Only professionals are allowed to offer hormone pellet therapy to the patients. So, there is absolutely no risk in the insertion procedure. However, patients might experience bleeding under the skin, infection, or transient discomfort in a few cases.


The Gluteal area is perfect for pellet insertion, and it is not uncommon to feel tenderness in those areas for a few weeks. Resting, avoiding high strength activity, and lower body exercises will soon heal the pain.


Digestive Issues


The inserted hormone pellets are new to your system. Of course, it will take a few days for your body to adjust its balance. In the meantime, you might experience minor digestive changes and related issues. Such as,

  • Diarrhea 
  • Constipation
  • Nausea 
  • Indigestion
  • Gastritis, etc.


There is nothing to worry about if you experience the side effects. These will go away within a few weeks.


Breast Cancer


The women are at risk of breast cancer if they continue the therapy for more than 5 years. According to experts, this claim is valid only when the patient takes both estrogen and progesterone.


Cardiovascular Disease


Older women on hormone pellets therapy have an increased risk of cardiovascular diseases. But of course, not all women.


The chance is higher for those who start hormone therapy in the 60s and continue taking estrogen and progesterone. For these reasons, professionals suggest taking this therapy early, within a few years of menopause.


Venous Thrombosis


Another risk of hormone pellet therapy is venous thrombosis—patients with this condition experience vein blockage due to blood clots. Venous thrombosis can be severe and cause permanent damage. Fortunately, the risk window of this disease is close to zero.


Change In Appetite


Hormone imbalance leads to weight fluctuation. You might be gaining or losing weight without changing your diet. As the hormones come in harmony with the pellets, you can get back to being healthy.


You will notice a difference in your appetite after the insertion of pellets. In the majority of cases, the change is beneficial for you.

Pros And Cons Of Hormone Pellets


Hormone pellet therapy has a few minor drawbacks, and there is no denial in that. Then why should you still go for this procedure instead of other hormone treatments or oral meds?

Symptoms Of Hormone Pellets Wearing Off

Weigh the pros and cons of this therapy and decide on your own,

Advantages Of Hormone Pellet Therapy


Easy And Risk-Free Implant: Taking medicines every day is a hassle. If you are in your 40s or 50s, you keep forgetting the dosage. Hormone pellets are far more compatible and effective, considering the situation. One time implant, and you are fit to go for up to 6 months.


Appreciable Consistency: The pills and creams work in the hormonal imbalance but give you a roller coaster effect. When you take the meds, your hormone level will be the highest, which drops as time goes by.


Now compare the effect to the pellets. These cylindrical supplements release a steady and consistent flow of hormones. So, you feel healthy and in control all the time.


Forgetting Is Not An Option: It never happens that I will not miss my course pills or injection at least one day. I am sure the same happens to you too. Sticking with pellets has no risk of forgetting as the supplements are already inside you and serving consistently.


Showering With Success: Have you ever seen the success rate of hormone pellet therapy? It is 95%. On the other hand, the satisfaction rate for creams and gels are 75% and 62%, respectively.


Drawbacks Of Hormone Pellet Therapy


Fear Of Implant: Many patients avoid pellet therapy because of the minor surgery procedure. Though the operation is risk-free and painless, the chances of infection or bleeding are minimum.


Side Effects: Hormone pellet therapy has a few minor side effects. It takes a few weeks to completely recover after the surgery and get back to active life.


Non Removable Pellets: The hormone pellets are non-removable, which increases the risk of over-treatment. Make sure your practitioner is highly trained and knows what he is doing.


Costly: Compared to other hormone therapies, pellet insertion is expensive. But considering the effectiveness and service, the price is quite fair.


The symptoms of hormone pellets wearing off are the indications for a renewal session. While these therapies are effective and work on point, they can be expensive. Weigh all the pros and cons before choosing any hormonal therapy keeping your health condition in mind.

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Dr. David Nazarian

Dr. Nazarian is board certified in Internal Medicine and practices integrative medicine in the heart of Beverly Hills. In his career he has worked in the Emergency Department as well as in the hospital setting as a hospitalist. He has extensive medical training in hormone replacement therapy.

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