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Weight Loss Peptides

According to 2020 research, the global rate of obesity and its associated illnesses, including type 2 diabetes, hypertension, and cardiovascular disease, is continuously rising [1]. The review also emphasized the development and emerging field of peptide research related to weight loss.

Peptides are well-supported in the literature as a weight-loss tool. To find out more about these peptides and how well they can aid in weight loss, continue reading. Visit our Hormone Replacement Therapy website for additional information.

What are weight loss peptides?

Weight loss peptides are small chains of amino acids that play a role in various physiological processes in the body. These peptides are designed to help people lose weight by influencing specific mechanisms.

Types of peptides for weight loss

Semaglutide: This peptide medication is approved to treat obesity and type 2 diabetes. The Food and Drug Administration (FDA) has approved it, and it is normally administered by injection once a week. This medication appears to have good effects over the first year of treatment and may plateau by week 60.
Liraglutide: Liraglutide is another GLP-1 receptor agonist that has been licensed especially for weight loss. According to researchers, it suppresses hunger and aids in weight loss that lasts at least a year. Usually, an injection of this drug is administered once daily.
Tirzepatide: It is another GLP-1 receptor agonist used to treat type 2 diabetes. In research involving approximately 2,500 adults, those who took different dosages of tirzepatide over the course of 72 weeks had a significant and long-lasting decrease in weight compared to those who got a placebo.
Tesamorelin: One well-known treatment for HIV-associated lipodystrophy is tesamorelin. This putative peptide has been shown in clinical trials to decrease visceral adipose tissue (VAT), especially in the abdominal area.
AOD 9604: AOD 9604 is a growth hormone fragment. It inhibits the body from producing new fat and aids in the breakdown of fat. It uses the body’s stored fat to keep new fat from accumulating and ultimately results in weight loss.
Amino-1MQ: One medication that combats obesity is amino-1MQ. It functions by reducing the rate at which a cell enzyme burns fat. In order to avoid obesity, it also decreases blood cholesterol and maintains it at healthy levels.
CJC-1295: Growth hormone and insulin-like growth factor 1 are released by the body with the aid of CJC-1295. They aid in the breakdown of fat cells and promote lean body mass. It is considerably more effective at helping people lose weight when coupled with Ipamorelin.

How it works

Contact us at +1 424-283-4273 to schedule an in office consult or virtual consult

or Book Online to receive your prescription of Wegovy or other Semaglutide or Trizepatide for weight loss.

Virtual Consult with MD & Nutritionist $450
3 Month Supply of the best compounded semaglutide injection $750 ( Special Pricing)
Follow Ups $250
Lose 10 – 20% of body fat safely and effectively

Traditional Weight Loss Medications

Several popular drugs for weight loss include:

Orlistat (Alli, Xenical): It functions by preventing the breakdown of fat in the stomach, which reduces the amount of calories that come from fat.
Phentermine (Adipex-P, Lomaira): It functions by preventing the breakdown of fat in the stomach, which reduces the amount of calories that come from fat.
Bupropion and Naltrexone (Contrave): The brain regions that regulate hunger and food desires are targeted by these two medications.

Are there specific peptides that target different aspects of weight loss?

Appetite Suppression

Semaglutide: This peptide suppresses hunger in a manner similar to that of glucagon-like peptide 1 (GLP-1). It is frequently used to treat long-term weight-related disorders.
Tirzepatide: Another peptide that controls hunger and growth hormone levels and aids in weight loss.

Fat Metabolism

Tesofensine: A peptide that affects fat metabolism, tesofensine may help reduce weight despite its less well-known effects.
Naltrexone: Research has shown that naltrexone may affect fat metabolism and have implications for managing weight.

Muscle Preservation

Sermorelin: This peptide may assist in maintaining muscle mass while losing weight by influencing growth hormone levels.

Clinical Evidence and Research

Semaglutide

Researchers examined the efficacy of semaglutide and liraglutide in weight loss regimens that included both diet and exercise in a trial conducted in 2022. The results showed that after 68 weeks, semaglutide caused more weight loss than liraglutide. [2].

Liraglutide

According to a 2021 study, 277 participants who took 3 mg of liraglutide every day dropped 4.1 kg, or 9 pounds [3].

Tirzepatide

According to a study done on obese individuals, tirzepatide medication resulted in an average weight loss of 10%–20% of the subjects’ starting body weight after 72 weeks [4].

AOD9604

A paper presented the results of a 12-week experiment demonstrating that individuals who are overweight can lose weight with a low dose of AOD9604 [5].

5-Amino-1MQ

5-Amino-1MQ was shown to be effective in decreasing the appearance of fat tissue by shrinking fat cells and preventing the buildup of fat [6].

Peptides For Weight Loss

Hormone Replacement Therapy offers the best peptides for weight loss near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

Gao Y, Yuan X, Zhu Z, Wang D, Liu Q, Gu W. Research and prospect of peptides for use in obesity treatment (Review). Exp Ther Med. 2020 Dec;20(6):234. doi: 10.3892/etm.2020.9364. Epub 2020 Oct 16. PMID: 33149788; PMCID: PMC7604735.
Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138–150. doi:10.1001/jama.2021.23619
Haase CL, Serratore Achenbach MG, Lucrezi G, Jeswani N, Maurer S, Egermann U. Use of Liraglutide 3.0 mg for Weight Management in a Real-World Setting in Switzerland. Obes Facts. 2021;14(5):568-576. doi:10.1159/000518325
Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. The New England Journal of Medicine. 2022;387(3):205-216. doi:https://doi.org/10.1056/nejmoa2206038
News Medical. Obesity drug codenamed AOD9604 highly successful in trials. News-Medical. Published December 16, 2004. Accessed February 28, 2024. https://www.news-medical.net/news/2004/12/16/6878.aspx
Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60(12):5015–5028.

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