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GLP-1 Medications

GLP-1 Medication - Hormone Replacement Therapy

GLP-1 medications are medicines that mainly help manage blood glucose levels in people with Type 2 diabetes [1]. But did you know it can also help in weight loss? Semaglutide and liraglutide are two FDA-approved drugs that are backed by research for their weight loss effects. To know more about GLP-1 agonists, keep reading this article. If you have any questions or want to lose weight using GLP-1 medications, visit us at Hormone Replacement Therapy LA.

How do GLP-1 drugs work?

Triggering Insulin Release: GLP-1 agonists stimulate the release of insulin from your pancreas. Insulin is an essential hormone that allows your body to use the food you eat for energy. It lowers the amount of glucose (sugar) in your blood. If you don’t have enough insulin, your blood sugar increases, leading to diabetes.

Blocking Glucagon Secretion: GLP-1 agonists block the secretion of glucagon, a hormone your body uses to raise your blood sugar levels when necessary. So, GLP-1 prevents more glucose from going into your bloodstream.

Slowing Stomach Emptying: GLP-1 agonists slow down the movement of food from the stomach into the small intestine, which means that your body releases less glucose (sugar) from the food you eat into your bloodstream1.

Increasing Satiety: GLP-1 agonists affect areas of your brain that process hunger and satiety, making you feel full after eating

Importance of GLP-1 medications for weight loss

Appetite Suppression: GLP-1 agonists can decrease appetite and promote weight loss, making their use for shedding weight increasingly popular.

Blood Sugar Control: Traditionally used to treat diabetes and lower blood sugar levels, GLP-1 agonists can also help in weight management in people with Type 2 diabetes.

Weight Loss: Studies have found that all GLP-1 drugs can lead to weight loss of about 10.5 to 15.8 pounds using liraglutide.

Cardiovascular Benefits: Research has found that some drugs in these groups may lower the risk of heart disease, such as heart failure, stroke, and kidney disease. GLP-1s and SGLT-2 inhibitors have improved the blood pressure and cholesterol levels of the users.

How it works

Contact us at +1 424-283-4273 to schedule an in office consult or virtual consult

or Book Online to receive your prescription of Wegovy or other Semaglutide or Trizepatide for weight loss.

  • Virtual Consult with MD & Nutritionist $450
  • 3 Month Supply of the best compounded semaglutide injection  $750 ( Special Pricing) 
  • Follow Ups $250
  • Lose 10 – 20% of body fat safely and effectively
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Side effects of GLP-1 drugs

  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Bloating
  • Indigestion
  • Headache
  • Redness, itching, or soreness of the skin at the injection site 

What is the best GLP-1 for weight loss?

Two types of GLP-1 agonists are approved for chronic weight management for people with overweight or obesity (without type 2 diabetes): Wegovy and Saxenda. Other GLP-1 agonists, such as Ozempic, are approved for the treatment of type 2 diabetes but may also be prescribed off-label for weight loss in some cases.

A study found people who took semaglutide in addition to diet and exercise had 9.4% more weight loss compared to the results of liraglutide [2].

Are GLP-1 medications suitable for people with heart disease?

Yes, GLP-1 agonists like Ozempic and Wegovy, which are also used for weight loss, may have cardiovascular benefits. 

Are GLP-1 medications suitable for people with heart disease

A large, randomized, controlled trial found that semaglutide, the compound on which these drugs are based, significantly reduced the number of cardiac events in people without diabetes who had pre-existing cardiovascular disease [3].

Which GLP-1 agonist is the cheapest?

Keeping the price list of Goodrx.com in mind, Trulicity (dulaglutide) is the cheapest ones out of all the others. Here’s the price list for the agonists:

  • Byetta (exenatide) – $1,200
  • Bydureon (exenatide ER) – $1,500
  • Adlyxin (lixisenatide) – $1,500
  • Victoza (liraglutide) – $1,160
  • Trulicity (dulaglutide) – $968
  • Ozempic (semaglutide) – $973
  • Saxenda (liraglutide) – $1,302
  • Wegovy (semaglutide) – $1,302

Is metformin a GLP-1 drug?

No, metformin isn’t a GLP-1 drug. It belongs to a class of drug called biguanides and works at lowering glucose levels produced by the liver and improving insulin sensitivity [4].

Is GLP-1 better than metformin?

A study published in the journal Diabetes Care compared the efficacy of the agonists with metformin for type 2 diabetes treatment. They found that GLP-1 receptor agonists were more effective than metformin in lowering body weight and HbA1c levels. With that said, metformin is still considered the primary medication for type 2 diabetes treatment and GLP-1 agonists come as the secondary treatment [5].

GLP-1 Medications Near Me

Hormone Replacement Therapy LA offers the best hormonal acne treatment near me in Beverly Hills but can also come to your home or office throughout the Los Angeles area. We serve patients near Beverly Hills, Bel Air, West Hollywood, Santa Monica, West Los Angeles, Culver City, Hollywood, Venice, Marina del Rey, Malibu, Manhattan Beach, Redondo Beach, Downtown Los Angeles, Encino, Woodland Hills, Sherman Oaks, Calabasas, Burbank, Glendale, Hidden Hills, Agoura Hills, Northridge, North Hollywood, Topanga, Canoga Park, Reseda, Valley Glen, Chatsworth, West Hills, Winnetka, Universal City, Silverlake, Echo Park, and many more.

References:

  1. Collins L, Costello RA. Glucagon-Like Peptide-1 Receptor Agonists. [Updated 2023 Jan 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551568/
  2. Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138–150. doi:10.1001/jama.2021.23619
  3. Sattar N, Lee MMY, Kristensen SL, Branch KRH, Del Prato S, Khurmi NS, Lam CSP, Lopes RD, McMurray JJV, Pratley RE, Rosenstock J, Gerstein HC. Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials. Lancet Diabetes Endocrinol. 2021 Oct;9(10):653-662. doi: 10.1016/S2213-8587(21)00203-5. Epub 2021 Aug 20. PMID: 34425083.
  4. Edoardo Mannucci, Agostino Ognibene, Francesco Cremasco, Gianluca Bardini, Antonella Mencucci, Enrica Pierazzuoli, Silvia Ciani, Gianni Messeri, Carlo M. Rotella; Effect of Metformin on Glucagon-Like Peptide 1 (GLP-1) and Leptin Levels in Obese Nondiabetic Subjects. Diabetes Care 1 March 2001; 24 (3): 489–494. https://doi.org/10.2337/diacare.24.3.489
  5. Muhammad Abdul-Ghani, Ralph A. DeFronzo; Is It Time to Change the Type 2 Diabetes Treatment Paradigm? Yes! GLP-1 RAs Should Replace Metformin in the Type 2 Diabetes Algorithm. Diabetes Care 1 August 2017; 40 (8): 1121–1127. https://doi.org/10.2337/dc16-2368

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